Korelasi Body Age dengan Lemak Tubuh pada Perempuan Dewasa Muda
Abstract
Proses penuaan pada perempuan dewasa muda mengalami perubahan yang kompleks terutama pada perubahan distribusi lemak akibat perubahan hormonal seiring bertambahnya usia. Body age atau usia biologis merupakan sebuah indikator yang digunakan untuk mengetahui usia dari organ seluler, sebagai gambaran fisiologis seseorang. Penelitian ini bertujuan untuk menganalisis hubungan antara body age dengan parameter lemak tubuh pada perempuan dewasa muda. Desain penelitian yang digunakan adalah analitik observasional dengan pendekatan cross sectional. Beberapa data individu menunjukkan body age yang relatif rendah meski memiliki persentase lemak tubuh tinggi, sementara individu lain memiliki pola sebaliknya. Hal ini menunjukkan faktor lain baik eksternal maupun internal juga menentukan usia biologis. Terdapat hubungan positif yang kuat antara akumulasi lemak tubuh dengan percepatan penuaan biologis pada perempuan dewasa muda. Temuan mengkonfirmasi pentingnya manajemen komposisi tubuh untuk pencegahan penuaan biologis dini dan optimalisasi kesehatan perempuan.
Downloads
References
Aldobali, M., & Pal, K. (2021). Bioelectrical Impedance Analysis for Evaluation of Body Composition: A Review. 2021 International Congress of Advanced Technology and Engineering, ICOTEN 2021, July. https://doi.org/10.1109/ICOTEN52080.2021.9493494
Ashiqur Rahman, S., Giacobbi, P., Pyles, L., Mullett, C., Doretto, G., & Adjeroh, D. A. (2021). Deep learning for biological age estimation. Briefings in Bioinformatics, 22(2), 1767–1781. https://doi.org/10.1093/bib/bbaa021
Balasubramanian, P., Kiss, T., Gulej, R., Nyul Toth, A., Tarantini, S., Yabluchanskiy, A., ... & Csiszar, A. (2024). Accelerated aging induced by an unhealthy high-fat diet: initial evidence for the role of Nrf2 deficiency and impaired stress resilience in cellular senescence. Nutrients, 16(7), 952.
Banack, H. R., Cook, C. E., Grandi, S. M., Scime, N. V., Andary, R., Follis, S., ... & Odegaard, A. O. (2024). The association between reproductive history and abdominal adipose tissue among postmenopausal women: results from the Women’s Health Initiative. Human Reproduction, 39(8), 1804-1815.
Correia, E. S., Godinho-Mota, J. C. M., Schincaglia, R. M., Martins, K. A., Martins, J. S., Vilella, P. R., Soares, L. R., & Vaz-Gonçalves, L. (2022). Metabolic Syndrome in postmenopausal women: prevalence, sensibility, and specificity of adiposity indices. Clinical Nutrition Open Science, 41, 106–114. https://doi.org/10.1016/j.nutos.2022.01.001
Frasca, D., & Blomberg, B. B. (2016). Inflammaging decreases adaptive and innate immune responses in mice and humans. Biogerontology, 17(1), 7–19. https://doi.org/10.1007/s10522-015-9578-8
Ibrahim, M. M. (2019). Subcutaneous and visceral adipose tissue: Structural and functional differences. Obesity Reviews, 11(1), 11–18. https://doi.org/10.1111/j.1467-789X.2009.00623.x
Kim, H., Heo, J. H., Lim, D. H., & Kim, Y. (2023). Development of a Metabolic Syndrome Classification and Prediction Model for Koreans Using Deep Learning Technology: The Korea National Health and Nutrition Examination Survey (KNHANES) (2013–2018). Clinical Nutrition Research, 12(2), 138. https://doi.org/10.7762/cnr.2023.12.2.138
Kusminski, C. M., & Scherer, P. E. (2012). Mitochondrial dysfunction in white adipose tissue. Trends in Endocrinology and Metabolism, 23(9), 435–443. https://doi.org/10.1016/j.tem.2012.06.004
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023). Hallmarks of aging: An expanding universe. Cell, 186(2), 243–278. https://doi.org/10.1016/j.cell.2022.11.001
Lu, Y., Pechlaner, R., Cai, J., Yuan, H., Huang, Z., Yang, G., Wang, J., Chen, Z., Kiechl, S., & Xu, Q. (2020). Trajectories of Age-Related Arterial Stiffness in Chinese Men and Women. Journal of the American College of Cardiology, 75(8), 870–880. https://doi.org/10.1016/j.jacc.2019.12.039
Marquardt, J. P., Tonnesen, P. E., Mercaldo, N. D., Graur, A., Allaire, B., Bouxsein, M. L., ... & Fintelmann, F. J. (2024). Subcutaneous and Visceral Adipose Tissue Reference Values From the Framingham Heart Study Thoracic and Abdominal CT. Investigative Radiology, 10-1097.
Mundstock, E., Sarria, E. E., Zatti, H., Mattos Louzada, F., Kich Grun, L., Herbert Jones, M., Guma, F. T. C. R., Mazzola, J., Epifanio, M., Stein, R. T., Barbé-Tuana, F. M., & Mattiello, R. (2015). Effect of obesity on telomere length: Systematic review and meta-analysis. Obesity, 23(11), 2165–2174. https://doi.org/10.1002/oby.21183
Nordling, Y., Sund, R., Sirola, J., Kröger, H., Isanejad, M., & Rikkonen, T. (2024). Body composition, balance, functional capacity and falls in older women. Aging Clinical and Experimental Research, 36(1). https://doi.org/10.1007/s40520-024-02719-5
Pallavi Karn. (2023). Nutritional Status And Menopausal Symptoms Of Postmenopausal Women Residing In Biratnagar-10 , Pallavi Karn Department of Nutrition and Dietetics Nutritional status and Menopausal Symptoms of Postmenopausal Women Residing in Biratnagar-10 , Nepal Departme.
Porter, L. C., Franczyk, M. P., Pietka, T., Yamaguchi, S., Lin, J. B., Sasaki, Y., Verdin, E., Apte, R. S., & Yoshino, J. (2018). NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism. American Journal of Physiology - Endocrinology and Metabolism, 315(4), E520–E530. https://doi.org/10.1152/ajpendo.00057.2018
Rodriguez-Ayllon, M., Cadenas-Sánchez, C., Estévez-López, F., Muñoz, N. E., Mora-Gonzalez, J., Migueles, J. H., Molina-García, P., Henriksson, H., Mena-Molina, A., Martínez-Vizcaíno, V., Catena, A., Löf, M., Erickson, K. I., Lubans, D. R., Ortega, F. B., & Esteban-Cornejo, I. (2019). Role of Physical Activity and Sedentary Behavior in the Mental Health of Preschoolers, Children and Adolescents: A Systematic Review and Meta-Analysis. Sports Medicine, 49(9), 1383–1410. https://doi.org/10.1007/s40279-019-01099-5
Sebastiani, P., Thyagarajan, B., Sun, F., Schupf, N., Newman, A. B., Montano, M., & Perls, T. T. (2017). Biomarker signatures of aging. Aging Cell, 16(2), 329–338. https://doi.org/10.1111/acel.12557
Shuster, A., Patlas, M., Pinthus, J. H., & Mourtzakis, M. (2016). The clinical importance of visceral adiposity: A critical review of methods for visceral adipose tissue analysis. British Journal of Radiology, 85(1009), 1–10. https://doi.org/10.1259/bjr/38447238
Thesis, D. (2025). Body fat distribution and obesity : a comparison of upper and lower body adipose tissue biology in humans (Issue 2023). https://doi.org/10.26481/dis.20231019ll
Welty, F. K., Alfaddagh, A., & Elajami, T. K. (2016). Targeting inflammation in metabolic syndrome. Translational Research, 167(1), 257–280. https://doi.org/10.1016/j.trsl.2015.06.017
Copyright (c) 2025 Ahmad Abdullah, Ahmad Fahmil Makarim, Miftahunur Haselli, Muchamad Rafigo
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
